| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 110201 | 100 ug | $140 | ||
| 110202 | 500 ug | $320 |
| Clone | 184AM1 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | Purified |
| Target Name | CD184, CXCR4 |
| Isotype | Mouse IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.25 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application |
CD184 (CXCR4, Fusin) is a 45-kDa, seven-transmembrane G-protein–coupled CXC chemokine receptor widely expressed on blood and tissue cells, including B and T cells, monocytes, macrophages, dendritic cells, granulocytes, megakaryocytes/platelets, endothelial and epithelial cells, astrocytes, and neurons. It serves as the receptor for the chemokine SDF-1/CXCL12, regulating cell migration, B lymphopoiesis, myelopoiesis, cardiogenesis, vascular development, and cerebellar formation. CD184 also functions as a co-receptor for X4 HIV-1 entry and as an alternative receptor for certain HIV-2 isolates.
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