| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 110801 | 100 ug | $35 | ||
| 110802 | 500 ug | $105 |
| Clone | BC96 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | Purified |
| Target Name | CD25, IL-2R α chain, Low affinity IL-2R |
| Isotype | Mouse IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
CD25 is a 55 kDa type I transmembrane glycoprotein and the alpha chain of the high-affinity interleukin-2 receptor (IL-2R). It is expressed on activated T and B cells, progenitor lymphocytes, activated monocytes/macrophages, and a subset of non-stimulated CD4⁺ regulatory T cells (Tregs). CD25 associates with the IL-2 receptor β (CD122) and common γ (CD132) chains to form the functional high-affinity IL-2R complex. Functionally, CD25 is critical for T cell activation, proliferation, and immune regulation. Deficiency of CD25 in mice causes severe autoimmunity and lethal lymphoproliferative disorders, mirroring defects seen in FOXP3 deficiency. In humans, genetic studies and case-control analyses have linked CD25 to autoimmune diseases such as Graves’ disease, often accompanied by elevated soluble IL-2Rα (sIL-2Rα). Its role in immune regulation also makes it a target in certain cancer immunotherapies.
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