| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 109401 | 100 ug | $35 | ||
| 109402 | 500 ug | $90 |
| Clone | HI100 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | Purified |
| Target Name | CD45RA, GP180, LY5, LCA, PTPRC |
| Isotype | Mouse IgG2b |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage and Handling | The antibody solution should be stored between 2°C and 8°C |
CD45RA is a 205–220 kDa isoform of the CD45 tyrosine phosphatase, expressed on naïve/resting T cells, medullary thymocytes, B cells, and monocytes. It is found on ~40–50% of peripheral CD4⁺ T cells, ~50% of CD8⁺ T cells, and subsets of B cells and monocytes. CD45RA enhances TCR and BCR signaling and associates with molecules like LPAP, CD1–CD4, and galectin-1. Its expression is regulated by cytokines and can be present on some activated T cells. CD45RA-specific antibodies (e.g., HI100) are widely used to identify naïve T cells and study CD4⁺ suppressor/inducer subsets.
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