| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 110601 | 100 ug | $120 |
| Clone | 4S.B3 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | Purified |
| Target Name | IFNg, IFN-g, IFN-gamma, Interferon-γ |
| Isotype | Mouse IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
Human Interferon gamma (hIFN-γ) is the sole member of Type II interferons and a potent macrophage-activating cytokine produced mainly by activated T lymphocytes and natural killer (NK) cells. Structurally, it is an antiparallel homodimeric glycoprotein of approximately 45 kDa, consisting of two identical 146-amino-acid subunits. Binding of hIFN-γ to its receptor (IFN-γR1) activates the JAK/STAT signaling pathway, leading to the transcription of genes involved in antiviral, antibacterial, and immunoregulatory responses. Functionally, hIFN-γ upregulates MHC class I and II expression, enhances antigen presentation, and promotes Th1-type immune responses. It recruits and activates macrophages, NK cells, and cytotoxic T lymphocytes (CTLs), reinforcing innate and adaptive immunity. Although crucial for host defense, IFN-γ can also contribute to immune escape and tumor resistance in certain cancers.
Have a product or application question? Consult our FAQs or contact us.
