| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 110701 | 500 ug | $110 |
| Clone | MP4-25D2 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | Purified |
| Target Name | IL-4, Interleukin-4, MCGF-2 (Mast cell growth factor-2), MFF (Macrophage fusion factor), TCGF-2 (T cell growth factor-2) |
| Isotype | Rat IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, mast cells, and bone marrow stromal cells. It plays a central role in adaptive immunity, regulating T and B cell proliferation, survival, gene expression, and differentiation. IL-4 directs naive CD4⁺ T cells (Th0) into Th2 cells and promotes immunoglobulin class switching to IgG1 and IgE, while stimulating B-cell activation, T-cell proliferation, and macrophage polarization to M2 phenotype, contributing to allergic inflammation, wound repair, and tissue remodeling. IL-4 signals through two receptor complexes: the Type I receptor (IL-4Rα/γc) on hematopoietic cells, critical for Th2 differentiation, and the Type II receptor (IL-4Rα/IL-13Rα1) on non-hematopoietic cells, mediating airway hypersensitivity and mucus production. STAT6 is the key transcription factor in IL-4 signaling. Structurally, IL-4 is a compact globular protein stabilized by three disulfide bonds, featuring a four-alpha-helix bundle and a small beta-sheet, forming a stable functional fold.
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