| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 201501 | 100 ug | $55 | ||
| 201502 | 500 ug | $110 |
| Clone | 6D5 |
|---|---|
| Application | FC |
| Reactivity | Mouse |
| Format | Purified |
| Target Name | CD19, B4, CVID3, Leu-12, MGC12802 |
| Isotype | Rat IgG2a |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage and Handling | The antibody solution should be stored between 2°C and 8°C |
CD19, also known as B-lymphocyte antigen CD19, B4, Leu-12, or CVID3, is a type I transmembrane glycoprotein encoded by the CD19 gene. It is expressed throughout B cell development from the pro-B stage to mature B cells and is present on most B lineage cells. CD19 functions as an adaptor protein, recruiting cytoplasmic signaling molecules to the membrane, and forms part of the CD19/CD21/CD81 complex, which lowers the activation threshold for B cell receptor (BCR) signaling. Because of its consistent expression on B cells, CD19 serves as a key biomarker for B cell development and is widely used in the diagnosis of B cell lymphomas and leukemias. It is also a major therapeutic target in immunotherapies, including CAR T-cell therapy for B cell malignancies.
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