| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 200501 | 100 ug | $90 | ||
| 200502 | 500 ug | $220 |
| Clone | MEL-14 |
|---|---|
| Application | FC |
| Reactivity | Mouse |
| Format | Purified |
| Target Name | CD62L, LAM-1, L-selectin, Ly-22 |
| Isotype | Rat IgG2a |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.5 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application. |
CD62L is a ~74–95 kDa (commonly ~75 kDa) single-chain type I transmembrane glycoprotein encoded by the SELL gene. It belongs to the selectin family of membrane-anchored, calcium-dependent C-type lectins (alongside CD62E and CD62P) that bind to specific carbohydrate ligands. Like other selectins, CD62L recognizes sialylated carbohydrate structures, including the Sialyl Lewis X (sLeX/CD15s) determinant, via its C-type lectin domain. High-affinity ligands include certain glycoforms of CD34, GlyCAM-1, and MAdCAM-1, while binding to sLeX-related oligosaccharides occurs with lower affinity.
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