| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 202401 | 100 ug | $100 | ||
| 202402 | 500 ug | $250 |
| Clone | K67AR2b |
|---|---|
| Application | FC |
| Reactivity | Human, Mouse |
| Format | Purified |
| Target Name | Ki-67, Ki67 |
| Isotype | Rat IgG2b |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide |
| Protein Concentration | 0.5 mg/mL |
| Storage&Handling | The antibody solution should be stored between 2°C and 8°C |
| Recommended Usage | For flow cytometric staining, it is recommended to use less than 0.25 ug of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application. |
Ki-67 is a nuclear protein expressed as two isoforms (395 and 345 kDa), each containing a forkhead-associated (FHA) domain and 16 Ki-67 repeats that include the epitope recognized by the Ki-67 monoclonal antibody. Ki-67 interacts with proteins such as Hklp2, hNIFK, and chromobox homologs 1, 3, and 5. Its expression is restricted to proliferating cells in the G1, S, G2, and M phases of the cell cycle, making it a robust marker of cell proliferation. Ki-67 is widely used in oncology as a prognostic factor, in studies of lymphocyte and myocyte proliferation, and as a marker of neuronal proliferation in various neuropathologies.
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