| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 800303 | 25 ug | $245 | ||
| 800304 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, APC |
| Expression Host | HEK293 |
| Target Name | CD16A,FCGR3A, FCG3, FCGR3, IGFR3, |
| Species | Human |
| Sources | Recombinant Human CD16a (Gly17-Gln208, V176) with C-terminus His is expressed in HEK293 cell and conjugated to APC. |
| Accession Number | P08637 |
| Molecular Weight | The protein has a predicted molecular weight of 25kDa. Under DTT-reducing conditions, it migrates at approximately 40–50 kDa on SDS-PAGE prior to APC conjugation. |
| Affinity Tag | C-His |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
CD16 is a low-affinity Fc receptor and exists in two isoforms: FcγRIIIa (CD16a) and FcγRIIIb (CD16b). These receptors bind to the Fc region of IgG antibodies with distinct tissue-specific expression pattern. CD16a is a transmembrane glycoprotein with intermediate affinity, expressed on natural killer (NK) cells, macrophages, subsets of T cells, immature thymocytes, and placental trophoblasts. In contrast, CD16b is a low-affinity, GPI-anchored receptor expressed primarily on neutrophils and eosinophils. CD16a plays a key role in mediating phagocytosis, antibody-dependent cellular cytotoxicity (ADCC), enzyme secretion, and immune complex clearance.
APC Conjugated Human CD16a Protein (C-His, 176V) TDS
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