| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 811803 | 25 ug | $245 | ||
| 811804 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, APC |
| Expression Host | CHO |
| Target Name | TNFRSF18, AITR, GITR, CD357 |
| Species | Human |
| Sources | Recombinant Human GITR/TNFRSF18 (Gln26-Glu161) with C-terminus Fc-tag is expressed in CHO cell and conjugated to APC. |
| Accession Number | Q9Y5U5 |
| Molecular Weight | The protein has a predicted molecular weight of 40.8 kDa. Under DTT-reducing conditions, it migrates at approximately 45-50 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-Fc |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
GITR (glucocorticoid-induced TNFR-related protein), also known as TNFRSF18 or CD357, is a 25 kD member of the TNF receptor superfamily that acts as the receptor for TNFSF18 (GITRL). It is primarily expressed on activated T cells and regulatory T cells and is upregulated upon T cell receptor engagement. GITR plays a key role in immune regulation by influencing T cell proliferation, TCR-mediated apoptosis, and the function of regulatory T cells, thereby contributing to the maintenance of self-tolerance. GITR signaling activates NF-κB via the TRAF2/NIK pathway and interacts with TRAF1–3. It is also implicated in T cell–endothelial cell interactions and the pathogenesis of autoimmune diseases.
APC conjugated Human GITR (TNFRSF18) (C-Fc) TDS
Have a product or application question? Consult our FAQs or contact us.
