| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 813603 | 25 ug | $245 | ||
| 813604 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, APC |
| Expression Host | CHO |
| Target Name | PDL2, , Butyrophilin B7-DC, CD273, PDCD1 ligand 2 |
| Species | Human |
| Sources | Recombinant Human PD-L2 (Leu20-Pro219) with C-terminus Fc-tag is expressed in CHO cell and conjugated to APC. |
| Accession Number | Q9BQ51 |
| Molecular Weight | The protein has a predicted molecular weight of 48.8 kDa. Under DTT-reducing conditions, it migrates at approximately 65 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-Fc |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
Programmed death ligand 2 (PD-L2, also known as B7-DC or CD273) is a type I transmembrane protein and a member of the B7 family, containing one V-like and one C-like Ig domain in its extracellular region. It is mainly expressed on antigen-presenting cells, such as dendritic cells, macrophages, and B cells, and its expression can be induced by IFN-γ or LPS. PD-L2 serves as a high-affinity ligand for PD-1, a receptor expressed on activated T and B cells, and inhibits T cell activation, proliferation, and cytokine production, thus contributing to immune tolerance and evasion, particularly in tumors and autoimmunity. PD-L2 also plays a PD-1–independent role in asthma by regulating airway hyperresponsiveness through IL-12 production and binding to an alternative receptor, RGMb, involved in respiratory immune regulation. Its dual functions in both PD-1–dependent and independent pathways highlight PD-L2 as a critical immunoregulatory molecule and a potential therapeutic target in cancer, autoimmunity, and allergic diseases.
APC conjugated Human PD-L2 (C-Fc) TDS
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