| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 805903 | 25 ug | $245 | ||
| 805904 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, APC |
| Expression Host | CHO |
| Target Name | TROP2,TACSTD2, GA733-1, M1S1 |
| Species | Human |
| Sources | Recombinant Human Trop2 (Gln24-Thr274) with C-terminus His-Avi tag is expressed in CHO cell and conjugated to APC. |
| Accession Number | P09758 |
| Molecular Weight | The protein has a predicted molecular weight of 29 kDa. Under DTT-reducing conditions, it migrates at approximately 40-50 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-His |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
TROP-2, also known as TACSTD2, is a 35.7 kD protein that belongs to the EpCAM family. It is a cell surface receptor that can transduce calcium signals. Mutations of this gene are associated with gelatinous drop-like corneal dystrophy. TROP-2 is highly expressed in a variety of epithelial cancers, making it a potential therapeutic target. The cytoplasmic tail of TROP-2 contains potential phosphorylation sites and a phosphatidyl-inositol binding sequence, suggesting its role in signal transduction. As a member of a family of at least two type I membrane proteins, TROP-2 is closely related to EpCAM, also known as TROP-1, and may play a role in regulating carcinoma cell growth.
APC Conjugated Human Trop2 Protein (C-His) TDS
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