| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 802201 | 25 ug | $145 | ||
| 802202 | 100 ug | $295 |
| Application | ELISA, BLI |
|---|---|
| Format | Liquid, Purified |
| Expression Host | HEK293 |
| Target Name | TNFRSF17, CD269, BCM, BCMA |
| Species | Human |
| Sources | Human BCMA protein (NP_001183.2) (Met1-Ala54) with C-terminus Human IgG1 Fc-Avi tag is expressed in HEK293 cells. |
| Accession Number | Q02223 |
| Molecular Weight | The protein has a predicted molecular weight of 34.3kDa. Under DTT-reducing conditions, it migrates at approximately 35-45 kDa on SDS-PAGE. |
| Affinity Tag | C-Fc-Avi |
| Purity | >95% based on SDS-PAGE under reducing condition |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.22 µm filtered |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.2mg/mL concentration. 100 µg size is supplied at a lot-specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial can be stored at 4°C for up to 2 weeks, or at -20°C or below for up to six months. The protein may be further diluted to 0.1 mg/mL using 0.22 µm-filtered PBS buffer (pH 7.4). For long-term storage, the diluted stock solution should be aliquoted and stored at ≤ –70°C to minimize freeze-thaw cycles. If additional dilution is required, carrier proteins such as FBS or BSA should be added to maintain protein stability. |
CD269, also known as B-cell maturation antigen (BCMA), is a 27 kD single-pass transmembrane protein that contains one TNFR-Cys repeat in its extracellular domain. This protein is a critical factor for the long-term survival and maintenance of plasma cells and plays an essential role in B-cell maturation. CD269 is expressed by plasmablasts, plasma cells, and germinal center B cells, and it is primarily involved in regulating humoral immunity. The ligands for CD269 include BAFF (B-cell activating factor) and APRIL (A proliferation-inducing ligand). These ligands bind to CD269, initiating a signaling cascade that supports B-cell survival and plasma cell function. Additionally, the cytoplasmic domain of CD269 interacts with several members of the TRAF (tumor necrosis factor receptor-associated factor) family, which are important for transducing survival and proliferation signals within the cell. Due to its essential role in immune response regulation, CD269 is a key player in the development and functioning of plasma cells.
Human BCMA Protein (C-Fc-Avi) TDS
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