| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 101403 | 25 tests | $80 | ||
| 101404 | 100 tests | $220 |
| Clone | 279AM1 |
|---|---|
| Application | FC |
| Reactivity | Human |
| Format | iF560 |
| Target Name | CD279, PD1, PD-1 |
| Isotype | Mouse IgG1 |
| Antibody Type | Monoclonal |
| Regulatory Status | RUO |
| Formulation | Phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide and 0.2% (w/v) BSA |
| Protein Concentration | Supplied at a lot-specific concentration. |
| Storage&Handling | The antibody solution should be stored undiluted between 2°C and 8°C, and protected from prolonged exposure to light. Do not freeze. |
| Recommended Usage | For flow cytometric staining, it is recommended to use 5 uL of this reagent per 0.5-1.0 million cells in a 100 µL volume. Optimal reagent performance should be determined by titration for each specific application. |
| Excitation Laser | Green/Yellow laser (532/561nm) |
CD279, also known as Programmed cell death 1 (PD-1), cell surface receptor which binds to PD-L1 and PD-L2 ligands; functions as immune checkpoint with important role in down regulating immune system by preventing T-cell activation. Targeted by Nivolumab, Pembrolizumab and other monoclonal antibodies in a new class of cancer drugs. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. The interaction with CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.
iF560 Mouse IgG1 Isotype Control
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