| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 817701 | 25 ug | $245 | ||
| 817702 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, PE |
| Expression Host | CHO |
| Target Name | CD86, B7-2, B70, CD28LG2 |
| Species | Human |
| Sources | Recombinant Human B7-2 (CD86) (Leu20-Pro247) with C-terminus Fc-tag is expressed in CHO cell and conjugated to PE. |
| Accession Number | P05408 |
| Molecular Weight | The protein has a predicted molecular weight of 52.1 kDa. Under DTT-reducing conditions, it migrates at approximately 75 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-Fc |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
CD86 (B7-2) is a member of the immunoglobulin superfamily, expressed predominantly as a monomer on cell surfaces, and interacts with co-stimulatory receptors CD28 and CTLA-4 on T cells. This interaction regulates T cell activation, tolerance, cytokine production, and the generation of cytotoxic T lymphocytes (CTL). CD86 plays a critical role in promoting B and T helper cell interactions, supporting B cell proliferation and IgG secretion, particularly in B cell lymphomas. It also contributes to the development of a mature antigen-presenting cell (APC) repertoire, enhancing APC function and survival. CD86 is involved in chronic hemodialysis, allergic pulmonary inflammation, arthritis, and antiviral responses, positioning it as a potential target for immune therapies.
PE conjugated Human B7-2 (CD86) (C-Fc) TDS
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