| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 807401 | 25 ug | $245 | ||
| 807402 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, PE |
| Expression Host | CHO |
| Target Name | CD19, B4, CVID3 |
| Species | Human |
| Sources | Recombinant Human CD19 Protein (Glu21-Lys291) with C-terminus Fc-tag is expressed in CHO cell and conjugated to PE. |
| Accession Number | P15391 |
| Molecular Weight | The protein has a predicted molecular weight of 56.2 kDa. Under DTT-reducing conditions, it migrates at approximately 70-80 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-Fc |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
Cluster of Differentiation 19 (CD19) is a 95 kDa type I transmembrane glycoprotein and a member of the immunoglobulin superfamily, expressed on B cells from the early pro-B stage through to activated B blasts, but absent on plasma cells. It is also present on follicular dendritic cells. CD19 functions as a crucial co-receptor in B cell signaling by forming a complex with CD21 (CR2) and CD81 (TAPA-1), which enhances the sensitivity of B cells to antigens by lowering the activation threshold. Upon antigen binding, CD19 is phosphorylated, recruits Src-family kinases and PI3K, and internalizes with surface immunoglobulin (sIg), promoting downstream signal transduction necessary for B cell development, activation, and differentiation. Mutations in CD19 are linked to immunodeficiency syndromes with impaired antibody production, and CD19 is a key target in immunotherapy, particularly CAR-T cell treatment of B-cell malignancies.
PE Conjugated Human CD19 Protein (C-Fc) TDS
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