| Cat # | Size | Price | Quantity | |
|---|---|---|---|---|
| 810601 | 25 ug | $245 | ||
| 810602 | 100 ug | $595 |
| Application | FC |
|---|---|
| Format | Liquid, PE |
| Expression Host | CHO |
| Target Name | CD3-epsilon, FLJ18683, T3E, TCRE, CD3E |
| Species | Human |
| Sources | Recombinant Human CD3 Protein ( Asp 23- Asp126) with C-terminus Fc-tag is expressed in CHO cell and conjugated to PE. |
| Accession Number | P07766 |
| Molecular Weight | The protein has a predicted molecular weight of 37.9 kDa. Under DTT-reducing conditions, it migrates at approximately 45 kDa on SDS-PAGE prior to conjugation. |
| Affinity Tag | C-Fc |
| Regulatory Status | RUO |
| Formulation | 1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein |
| Endotoxin level | Not tested |
| Protein Concentration | 25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration. |
| Storage and Handling | Briefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months. |
CD3ε is a critical component of the T cell receptor (TCR)-CD3 complex, a transmembrane receptor essential for antigen recognition and T cell activation. It is a single-pass type I membrane glycoprotein containing an Ig-like extracellular domain and a cytoplasmic ITAM motif, which initiates intracellular signaling upon phosphorylation by Src family kinases (e.g., LCK, FYN). The TCR-CD3 complex includes two CD3ε chains, CD3γ, CD3δ, CD3ζ, and a TCR α/β or γ/δ heterodimer. CD3ε is expressed on all mature T cells, NK T cells, and some thymocytes, playing a vital role in T cell development and immune response. Mutations in CD3E disrupt T cell maturation and can lead to severe combined immunodeficiency (SCID), as well as increased susceptibility to autoimmune diseases such as type I diabetes.
PE conjugated Human CD3 (C-Fc) TDS
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