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PE Conjugated Human Trop1/EpCAM Protein (C-His)

Cat # Size Price Quantity
80650125 ug$245
806502100 ug$595

  Bulk/Custom

Product Details

ApplicationFC
FormatLiquid, PE
Expression HostCHO
Target NameEPCAM, TROP1, TACSTD1, CD326, DIAR5, EGP2, EGP314, EGP40, ESA, GA733-2, HNPCC8, HNPCC-8, KS1, 4, KSA, M4S1, MIC18, MK1
SpeciesHuman
SourcesRecombinant Human Trop1 (Gln24-Lys265) with C-terminus His tag is expressed in CHO cell and conjugated PE.
Accession NumberP16422
Molecular WeightThe protein has a predicted molecular weight of 29 kDa. Under DTT-reducing conditions, it migrates at approximately 30-40 kDa on SDS-PAGE prior to conjugation.
Affinity TagC-His
Regulatory StatusRUO
Formulation1xPBS buffer, pH7.4, 0.09% NaN3 with a carrier protein
Endotoxin levelNot tested
Protein Concentration25µg size is bottled at 0.1mg/mL concentration. 100 µg size is bottled at lot specific concentration.
Storage and HandlingBriefly centrifuge the vial upon receipt. An unopened vial may be stored at 2–8°C for up to six months.

Background Information

Ep-CAM, also known as tumor-associated calcium signal transducer 1, epithelial cell surface antigen, epithelial glycoprotein 2 (EGP2), adenocarcinoma-associated antigen, and TROP1, is a 40 kD glycosylated type I transmembrane protein containing six disulfide bridges and one THYRO domain. It is highly expressed on normal epithelial cells, including those in bone marrow, colon, and lung, and is also found on carcinomas, particularly those of gastrointestinal origin. Recent studies have shown that Ep-CAM expression occurs during early erythrogenesis. As a homotypic calcium-independent cell adhesion molecule, it plays a role in carcinogenesis by inducing genes involved in cellular metabolism and proliferation. Ep-CAM has been identified as a potential immunotherapeutic target for the treatment of human carcinomas.

Data Sheets

PE Conjugated Human Trop1/EpCAM Protein (C-His) TDS

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